Biography
Biography: Magda Helmi
Abstract
It has been reported that excessive weight gain in pregnancy is associated with adverse maternal and fetal outcomes. Trying to reduce weight gain during pregnancy have the potential to reduce adverse outcomes, Interventions based on diet and physical activity, or metformin, in pregnancy could influence maternal and fetal weight and obstetric outcomes.
The purpose is to evaluate different methods used during antenatal care to reduce weight gain during pregnancy diet, exercise and metformin.
Methodology & Theoretical Orientation:
All 139 women in this study had a confirmed diagnosis of obesity with pregnancy (body mass index >30 kg/m2), these women were followed up during their course of pregnancy; data forms were completed once they had delivered. Cases were divided into three groups (A,B and C): (A) 54 on healthy meal; and (B) 47 on exercise and DASH diet, and (C) 20 on metformin 500mg twice daily. All groups were matched by age, height and weight. Comparison was in terms of early and late pregnancy complications. In A, B and C the rate of pregnancy-induced hypertension/pre-eclampsia was 43.7%, 23.3% and 13.9% respectively (P<0.020). Rates of gestational diabetes requiring insulin treatment in A and B, were 33.3% and 18.7% compared to 2.5% in group C, (P<0.004). The rate of intrauterine growth restriction was significantly low in C, 2.5% compared to 19.2% and 16.6% in A and B respectively, (P<0.046). Frequency of preterm labor and live birth rate was significantly better in C compared to A and B. Overall rate of miscarriages was 7.2%.
CONCLUSION:
In obese pregnant women, continuous use of metformin during pregnancy significantly reduced the rate of complication and improves outcome.