Dr Lei Jin
Institute of Reproductive and Child Health, China
Title: Association of peri-conceptional folic acid supplementation and risk of gestational diabetes mellitus
Biography
Biography: Dr Lei Jin
Abstract
The adverse effects of folic acid supplementation were mentioned in a few studies, including gestational diabetes mellitus (GDM). The objective of this study was to explore the association peri-conceptional folic acid supplementation and risk of GDM in Chinese women. The subjects were the singleton pregnant women who gave birth in Maternal and Child Hospital of Tongzhou District. The data were selected from the Prenatal Health Care Database of Tongzhou District, Beijing. A total of 15691 pregnancies are included in the study. All of the pregnant women underwent 75g oral glucose tolerance test (OGTT) at 24-28 gestational weeks in the maternal and Child hospital. The GDM diagnosis was verified by the inpatient medical records. Multivariate logistic regression model was used to adjust the confounders. The prevalence of GDM was 22.7%, and the proportion of folic acid or multiple micronutrients with folic acid supplementation was 89.0%, among the women. Compared to the women who didn’t take the tablets before or in pregnancy (reference group), the adjusted ORs of taking folic acid, taking folic acid regularly, and taking folic acid from pre-pregnancy and risk of GDM were 1.24 (95%CI: 1.07-1. 3), 1.20 (95%CI: 1.10-1.31), and 1.15 (95%CI: 1.05-1.26), respectively. Compared to the reference group, regularly use of folic acid tablets or multivitamin tablets from pre-pregnancy had a higher incidence of GDM [adjusted ORs were 1.31 (95%CI:1.11-1.55) and 1.44 (95%CI:1.21-1.71)], regularly or irregularly use multivitamin tablets during pregnancy also had a higher incidence of GDM [adjusted ORs were 2.03 (95%CI:1.36-3.04) and 1.18 (95%CI:1.01-1.39)]. Compare to the reference group, regularly taking folic acid supplementation before or after pregnancy both increased the risk of GDM [adjusted ORs were 1.36 (95%CI: 1.17-1.60) and 1.62 (95%CI: 1.13-2.33)]. Conclusion: Folic acid supplementation before or during pregnant period, especially when consuming regularly, may increase the risk of gestational diabetes mellitus.